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KMID : 0894520110150020143
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Development & Reproduction
2011 Volume.15 No. 2 p.143 ~ p.150
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Influence of Aqua and Balance Exercise on Tyrosine Hydroxylase Expression in the Substantia Nigra and Functional Recovery in Hemiparkinsonian Rat Model
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Lee Hyun-Min
Kim Bum-Soo
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Abstract
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The objective of this study was to determine the effect of exercise on a hemiparkinsonian rat model. Nigrostriatal dopamine cell lesions were produced by injecting 6-hydroxydopamine at the left medial forebrain bundle of rats. In this study, the rats were divided into the following 4 groups: the control group without any exercise, experimental group Ⅰ with aqua-exercise (ExpⅠ), experimental group Ⅱ with balance exercise (ExpⅡ) and experimental group Ⅲ with complex exercise (aqua-exercise＋balance exercise; (ExpⅢ)). Exercises were applied to all the experimental groups after the operation. In order to observe the dopaminergic cell loss, we assessed the level of tyrosine hydroxylase (TH) expression in the midbrain of rats, and performed the apomorphine-induced rotation test at postoperative days (PDs) 7, 14, and 21. Experimental groups had significantly higher TH-immunoreactivity and behavioral performance than the control group. However, there was no difference in TH-immunoreactivity and behavioral performance across the experimental groups. These results suggest that the application of aqua-exercise and balance exercise could suppress dopaminergic cell loss in the substantia nigra of rat brains and could increase behavioral recovery in hemiparkinsonian rats.
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KEYWORD
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Exercise, Parkinson disease, Tyrosine hydroxylase
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